As advocates for a safe and supportive recovery environment, we find it imperative to address a looming concern that has surfaced in our community – the dangers of Tianeptine, often sold under the street name Zaza. Our mission at WakeUp Carolina is to empower individuals on their recovery journey, and part of that empowerment involves being informed about potential threats.

In this blog post, we will delve into the hazards of Tianeptine, its impact on medication-assisted treatment, and provide resources for our community to navigate these challenges.

Understanding Tianeptine

Tianeptine, originally developed as an antidepressant, has gained popularity in recent years as a substance of misuse. Marketed under the street name Zaza, it is available over the counter and online, making it easily accessible to individuals seeking alternative pathways to alter their mood.

The Dangers of Tianeptine

  • Opioid-Like Effects: Tianeptine has opioid-like effects, affecting the brain’s opioid receptors. This can lead to feelings of euphoria and pain relief, making it a target for misuse. However, it is essential to recognize that Tianeptine is not approved for recreational use, and its potential for abuse is a significant concern.
  • Complications in Medication-Assisted Treatment (MAT): For those undergoing Medication-Assisted Treatment (MAT), such as methadone or buprenorphine, Tianeptine poses a threat to recovery. Its opioid-like properties may interfere with the effectiveness of MAT medications, complicating the treatment process.
  • Risk of Dependence and Withdrawal: Misuse of Tianeptine can lead to dependence, and abrupt cessation may result in withdrawal symptoms. Individuals may find themselves caught in a cycle of use to avoid withdrawal, exacerbating the challenges of substance dependence.

Community Action and Support

  • Education and Awareness: Stay informed about the dangers of Tianeptine and its potential impact on recovery. Share this knowledge within our community to raise awareness and safeguard each other’s well-being.
  • Utilize Support Resources: If you or someone you know is struggling with Tianeptine misuse, seek support from WakeUp Carolina. Our community organization offers resources, counseling, and a network of individuals dedicated to supporting one another on the path to recovery.
  • Access MAT Safely: If participating in Medication-Assisted Treatment, consult with healthcare professionals to ensure a comprehensive understanding of potential interactions and complications related to Tianeptine use.

As we confront the dangers of Tianeptine, let us reinforce our commitment to a resilient and informed recovery community. WakeUp Carolina is here to provide the necessary tools and resources for individuals to make informed decisions about their well-being. Together, we can navigate the complexities of recovery, supporting one another with compassion, understanding, and a shared dedication to a healthier, substance-free life.



  • Stanciu, C. N., Gnanasegaram, S. A., Ahmed, S., & Penders, T. M. (2019). Tianeptine Abuse and Dependence in Psychiatric Patients: A Review of 18 Case Reports in the Literature. Journal of Addiction Medicine, 13(1), 81–88.
    Kole, S., & Panicker, P. (2021). Tianeptine. In StatPearls [Internet]. StatPearls Publishing.
  • National Institute on Drug Abuse (NIDA). (2022). Commonly Used Drugs Charts. Retrieved from 
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